An interesting departure. (The Elder Scrolls 5: Skyrim)

In General, I know about crashes and other stuff that is happening with Skyrim, you can talk forever. But I had a interesting story here. Immediately stipulate that gglomerate suit - nothing found that would be exactly like mine. If you find something in the forums, then I apologize. And outset that quite well aware of the problems with mods, the is a bunch Wrybash + loot, have the latest version of skse, skyui and fnis. Here's the problem:
I played Skyrim, do not grieve, everything was fine. Reached level 18, no serious problems were met. Yes, there have been departures, but there is sky, there is rarely complete without them (thanks to the gazebo...)
And here the day before play in peace. Then I saved, turned off the game. After an hour run - will not ship, no saving. Crash to desktop without errors. Save does not load everything. I climbed up on the forums. Dug out a bunch of information about the bit-depth, sound, etc. All tried - helps nothing. Was going to delete but decided to follow the simplest of advice - restart the computer.
And lo and behold, the save loaded! BUT only until the next exit the game) Then reboot again in any way.
In principle it is possible to play, but still maybe there are people who faced and overcame such a problem? Should I build SLMP, such as the so-called (no ineed this glycomod I immediately cut). Their any mods thrown, but checked the compatibility in wrye bash mods compiled, the bash patch did. This is all before the game. Then a couple more mods added, but it was downbeat. In the end, conclude that the problem is that Skye is something loads into temporary files Windows or in the RAM. Although, of course, not a fact. I hope for your help, dear kirimovi)
PS reboots windows was preserved in all the places wherever possible (open world, taverns, dungeons) - the result is the same - when you re-enter the game and load any savestate fly by R. S.