New symptom. HANGS (Red Dead Redemption 2)

Just started today after opening a license to kill. (maybe it's not affected)
After a short game gradually begin to fail the steps on R and E ( when you collect the loot)
Then after about a minute the game hangs tightly closed in any way does not work.
Hanging in the task and accessed. Does not work half the Windows. It is impossible to turn off not restart (turns infinite loading) - Saves only disconnection from the mains power supply.

СпойлерMicrosoft Windows 10 Home
Intel HexaCore Xeon E5-1650, 3.2 GHz (32 x 100)(4.20 GHz)
4x4Gb (16,0 Gb) DDR3 (Samsung)
HUANANZHI X79 Gaming (g279k ver14 / G279T v6.0)
ACER [24.5 LCD] (1920x1080@144Hz)
NVIDIA GeForce GTX 1070Ti 8Gb (Gigabyte)
SPCC Solid State Disk (223 GB, SATA-III)