Do additional quests affect the ending? (The Witcher 3: Wild Hunt)

look, for example, if you help someone, for example, Vernon Roche or someone else with their quests, then in the mission where you need to protect ciri from hunting in caer morhen, they will help you and others so that to some extent side quests affect the plot, for example, helped Triss and the magicians to escape, even though Triss remained in the end, she helped me and the hunters for magicians switched to non-humans and in one of the story missions Zoltan could not help me, you know something like this =))

Aziflow
yes, they must be passed

Spoiler Spoiler
Just in the quest "The Last Wish" (59 hours played) I could no longer choose Yen (because I chose Triss,), after this quest I realized the mistake :(. And I went through the quest with Triss somewhere at 18:00: (.

of course it affects especially quests with Ciri