Crash when New game and loading the savegame. (Fallout 4)

When I start a new game and the saves. Can't understand why(License), driver, new, compatibility is changed, the cache is checked 8 times.
The most interesting in the new game black screen crash, and when loading the save game loading screen and then just crash.
Before that I played only 580 hours... Uninstalled and then downloaded again and now do wonder, though earlier when the current 200 to 250 hours played I've deleted and reinstalled the game rocked - there were no departures. And now... Stsuka the money is not back :(
Iron say.
1066, 16gb RAM, Windows 10х64, FX-8350 - 4.7.